In Resident Evil: The Umbrella Chronicles, the first aid spray is an item that appears once per level and will be automatically used when the player's health drops to zero, completely refilling the player's health (similarly to an 'extra life' item). It can also revive a partner without resuscitating or wasting your tablets. It can revive a dying player without the help of a partner provided that the player has equipped it before being sent into dying state since in this state, it restricts any other actions except for crawling and shooting. Additionally, players can carry up to 3 cans of First Aid Spray at a time. In Resident Evil 6, the First Aid Spray heals and restores all 6 blocks of health. It can restore and refill both characters' health at once, though it requires them to stand close to each other.
In Resident Evil 5, the first aid spray is a full heal item that can be purchased for 1,000 gold from Chapter 1-2 and onward, and can also be occasionally found throughout the game. ' A medicinal spray that completely restores one's health.'